A human gut organoid biobank to facilitate fundamental biomedical research and advanced disease modelling.
Characterized organoid lines and data
Our gut organoid biobank has been developed since 2023 in collaboration with the THAMES-IBD project led by Professor Nick Powell. Thanks to the kind sample donation from patients, the enthusiastic work of a team of clinicians, research nurses and lab assistants we have generated over 150 gut organoid lines from biopsies collected during endoscopy examinations. Our standardised pipeline ensures the successful progression of organoid lines from biopsies, through expansion, to cryopreservation.
Our aim is to provide high-quality organoid lines for scientists to support cutting-edge biomedical research.
Main characteristics
- Adult-stem cell derived organoids generated from human biopsy samples, that preserve major genetic, epigenetic and phenotypic characteristics of the tissue they are originated from.
- Strict quality controls ensure the organoid lines’ successful and long-term culturin.
- Origin of tissue: small intestine (ileum), large intestine (several regions of the colon), rectum.
- Disease background: our main focus is currently IBD: ulcerative colitis, Crohn’s disease. The biobank also contains large number of organoid lines generated from healthy donors.
Advantages
- The organoid lines are annotated with donor demographics,
- Treatment status and history,
- Concurrent medical conditions and medications
- Our lines often paired with peripheral blood samples.
Special thanks to our donors
We would like to express our endless gratitude to our donors. Without their contribution we would have not been able to build this large organoid biobank and facilitate advanced disease modelling based on organoid technology.
