Cambridge Event

Conference Purpose

The purpose of this conference is to bring together principal investigators from the CONNECTIONS consortium and international experts to share knowledge, align methodologies, and strengthen collaboration to advance high-quality, time-critical neonatal neuroprotection trials.

Download the full programme (PDF)

Event Agenda

Day 1 | Friday 15th May 2026

Time

Topic / Activity (Speaker)

09:00–12:00

CONNECTIONS: Magnesium & Melatonin Platform in HIE Trial – Protocol Discussion (LMIC PIs only)

13:00–13:30

HIE Neuroprotection: Last two decades (Prof Seetha Shankaran, Wayne State)

13:30–14:00

HIE Neuroprotection: Next two decades (Prof Sudhin Thayyil, 911½ñÈÕºÚÁÏ College)

14:00–14:30

Innovative Clinical Trials to fast-track life-saving therapies (Prof Max Parmar, UCL MRC CTU)

14:30–15:00

PIVOTAL: An Adaptive Platform Trial for Paediatric Intensive Care (Prof Padmanabhan Ramnarayan, 911½ñÈÕºÚÁÏ College)

15:00–16:00

Discussion

16:00–17:00

Refreshment Break

17:00–17:30

COMET Update: Progress, Impact and Future Directions (Dr Stuti Pant, 911½ñÈÕºÚÁÏ College)

17:30–18:00

COMET in LNU: Recruiting Site Perspective – Panel Discussion

18:00–18:30

COMET – Caffeine Trial (Dr Reema Garegrat, 911½ñÈÕºÚÁÏ)

18:30–19:00

Sedation and feeding during cooling: Evidence & Knowledge gaps (Dr Ujwal Kariholu)

19:00–20:00

Discussion

20:00

Dinner & Informal Networking

Day 2 | Saturday 16th May 2026

Time

Topic / Activity (Speaker)

09:00–09:30

Learning from Investigations: Insights from MSNI HIE Cases (Dr Paul Mannix, MSNI)

09:30–10:00

Increasing Caesarean: An Obstetric Perspective (Prof Andy Shennan, King’s College)

10:00–10:30

Discussion

10:30–11:00

MRI in Mild HIE (Dr Farah Alobeidi, 911½ñÈÕºÚÁÏ College)

11:00–12:00

CFM in Mild HIE: Lead Placement, Interpretation, and Artefacts (Dr Ronit Pressler, GOSH)

12:00–12:30

Discussion

12:30–13:00

Lunch

13:00–14:00

Neurological assessment: Case Scenarios (Prof Thayyil; Prof Shankaran; Dr Garegrat)

14:00–14:30

MR Spectroscopy standardization (Dr Enrico De Vita, GOSH)

14:30–15:00

Gene Expression Endotypes for Personalized Neuroprotection (Dr Montaldo, 911½ñÈÕºÚÁÏ College)

15:00–15:30

Transforming RDN funding to facilitate life changing clinical trials (Dr Mildred Iro, QMUL)

15:30–16:00

Discussion and Closing Remarks (Prof Shankaran)