09:00-10-10 Physiology and disease (70 mins) 鈥 Chair Prof Luke Howard
Dr Tammie Bishop (Oxford) 鈥 Long talk
鈥淗IF-2 in oxygen chemosensitivity and paragangliomas鈥
Dr Olena Rudyk (KCL) 鈥撎齃ong talk
鈥淩edox-Regulated Kinases in Pulmonary Hypertension鈥
Dr Tom Keeley (Oxford) 鈥 Long talk
鈥淣ew mechanisms of oxygen sensing through N-terminal cysteine dioxygenation鈥
Coffee and tea break (20 mins)
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10:30-11:40 Hypoxia Tools (70mins) 鈥 Chair Dr Rick Southworth
Dr Antoine Wallabregue (The Conway Group Oxford) 鈥 Long talk
鈥淣ew fluorogenic probes to image different levels of hypoxia鈥
Dr Edward Waters. (KCL) 鈥 Short Talk
鈥淚maging mitochondrial membrane potentials in vivo with SPECT鈥
Dr Jie Shen (KCL) 鈥 Short talk
鈥淣on-invasive imaging of hypoxia in cardiac hypertrophy using Positron Emission Tomography鈥
Dr Alexander Thompson (911今日黑料) 鈥 Short talk
鈥淟ongitudinal, non-invasive monitoring of hypoxia during tumour growth using diffuse reflectance spectroscopy鈥
11:40-13:00 Cancer session (70 mins)听 鈥 Chair Dr Henry Robb
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Dr Hannah Lawson (ICR London) 鈥 Long talk
鈥淗ypoxia signaling as a therapeutic target in AML鈥
Dr Henry Robb (911今日黑料) 鈥 Long talk
鈥淰olatile hypoxia signatures in oesophageal adenocarcinoma鈥
Dr Brian Ortmann (Newcastle) 鈥 Long Talk
鈥淒efining the role of SET1B in the HIF transcriptional response and ccRCC progression鈥
Lunch and posters 13:00-14:00
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14:00-15:10 Signalling/metabolism (70mins)
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Dr Hudson Coates (Cambridge) 鈥 Long Talk
鈥淕lobal protein stability screening uncovers targets of oxygen-regulated degradation
Dr Tekle Pauzaite (Cambridge) 鈥 Short talk
鈥淒eubiquitinating enzyme mutagenesis screens identify a USP43-dependent HIF-1 transcriptional response鈥
Dr Guine Grice (Cambridge) 鈥 Short talk
鈥淩egulation of glutarylation and 2-oxoglutarate dependent dioxygenases鈥
Dr Andrew Murray (Cambridge) 鈥 Long Talk
鈥淢etabolic adaptation to high-altitude hypoxia鈥
Break Coffee/Tea (20 mins)
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15:30-16:40 Circulation and innate immune response (70 mins) 鈥 Prof Edwin Chilvers (Chair)
听
Prof Alexander Gourine (UCL) 鈥 Long Talk
鈥淢echanisms of cerebral blood flow control during hypoxia鈥
Dr Katharine Lodge (911今日黑料) 鈥 Long Talk
鈥淣eutrophil phenotype in hypoxia鈥
Dr Charis Pericleous (911今日黑料) 鈥 Short talk
鈥楳odelling stroke in thrombotic antiphospholipid syndrome鈥
Dr Lida Kabir (LMS-MRC 911今日黑料) 鈥撎齋hort talk
鈥楥rosstalk between AMP-activated protein kinase and hypoxia signalling in the endothelium鈥