Browse through all publications from the Institute of Global Health Innovation, which our Patient Safety Research Collaboration is part of. This feed includes reports and research papers from our Centre. 

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BibTex format

@article{Abuga:2027:10.1016/j.langlo.2026.103976,
author = {Abuga, KM and Muriuki, JM and Mutua, AM and Wambui, KM and Mturi, N and Mohammed, S and Fondo, JK and Mwarumba, S and Ngetsa, CJ and Newton, CR and Maitland, K and Bejon, P and MacLennan, CA and Nairz, M and Scott, JAG and Williams, TN and Atkinson, SH},
doi = {10.1016/j.langlo.2026.103976},
journal = {Lancet Glob Health},
title = {Severe anaemia and invasive bacterial infections in Kenyan children: a 26-year hospital surveillance observational study.},
url = {http://dx.doi.org/10.1016/j.langlo.2026.103976},
year = {2027}
}
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TY  - JOUR
AB  - BACKGROUND: Severe anaemia is a major cause of hospital admission and mortality in children living in sub-Saharan Africa, but data on its association with invasive bacterial infection are sparse. We aimed to characterise severe anaemia and its association with invasive bacterial infection in Kenyan children. METHODS: In this retrospective observational study, we systematically collected admission data for children aged 1 month to 14 years admitted to Kilifi County Hospital, Kenya, between Aug 1, 1998, and July 31, 2024. We excluded children with missing haemoglobin data. We examined prevalence, trends, and factors associated with severe anaemia and very severe anaemia, and the association between severe or moderate anaemia and odds of bacteraemia. Anaemia severity was defined using WHO age-specific thresholds. FINDINGS: Of the 84 348 admissions, representing 64 499 unique children (28 232 [43·8%] females and 36 265 [56·2%] males), included in our analysis, 16 715 (19·8%) admissions had severe anaemia. Severe anaemia was associated with multiple, co-occurring risk factors, including sickle cell disease, malaria, HIV, and malnutrition. As malaria transmission declined (2004-09), the age distribution of severe anaemia shifted towards older children; cases in children aged 5-14 years increased from 16·4% during the high-transmission era (1998-2003) to 44·7% during the low-transmission era (2010-24). Compared with mild or no anaemia, severe anaemia was associated with higher odds of in-hospital mortality (adjusted odds ratio 2·1 [95% CI 1·9-2·3]) and bacteraemia (2·7 [2·5-3·0]), particularly with non-typhoidal Salmonella (6·1 [4·6-8·1]), Escherichia coli (5·7 [4·2-7·7]), Haemophilus influenzae (4·3 [3·0-6·4]), Streptococcus pneumoniae (3·5 [2·9-4·2]), and Klebsiella pneumoniae (
AU  - Abuga,KM
AU  - Muriuki,JM
AU  - Mutua,AM
AU  - Wambui,KM
AU  - Mturi,N
AU  - Mohammed,S
AU  - Fondo,JK
AU  - Mwarumba,S
AU  - Ngetsa,CJ
AU  - Newton,CR
AU  - Maitland,K
AU  - Bejon,P
AU  - MacLennan,CA
AU  - Nairz,M
AU  - Scott,JAG
AU  - Williams,TN
AU  - Atkinson,SH
DO  - 10.1016/j.langlo.2026.103976
PY  - 2027///
TI  - Severe anaemia and invasive bacterial infections in Kenyan children: a 26-year hospital surveillance observational study.
T2  - Lancet Glob Health
UR  - http://dx.doi.org/10.1016/j.langlo.2026.103976
UR  - https://www.ncbi.nlm.nih.gov/pubmed/42379203
ER  -
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