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Tom gave a talk and poster presentation on the Tate groups’ research into small molecule inhibitors of the enzyme Hedgehog acyltransferase (Hhat)

The work was presented in Brighton this month at the Biochemical Society’s meeting entitled  Tom was also awarded a prize for his accompanying poster.

Hhat is a and its activity is required for Hedgehog signalling which promotes growth in certain cancers, thus making Hhat a . The Tate group has developed synthetic routes to the , along with means to modulate their . These inhibitors have been analysed using a chemical biology approach to identify an , RUSKI-201. The group has also designed new biochemical assays for Hhat activity, using or formats. These tools will support further development of Hhat inhibitors in future.