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• Conference paper
  Ghani R, Gan C, Mullish BH, Ferizoli V, Davies F, Thursz MR, Marchesi JR, Dasgupta R, Minhas Set al., 2019,
  , British Association of Urological Surgeons Annual Scientific Meeting, Publisher: SAGE Publications, Pages: 83-85, ISSN: 2051-4158
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• Journal article
  Allegretti JR, Kassam Z, Chiang AL, Mullish BH, Carrellas M, Hurtado J, Marchesi J, McDonald JA, Pechlivanis A, Barker GF, Blanco JM, Wong WF, Geradin Y, Silverstein M, Kennedy K, Thompson CCet al., 2019,
  , Gastroenterology, Vol: 156, Pages: S-129-S-129, ISSN: 0016-5085
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• Journal article
  Allegretti JR, Hurtado J, Carrellas M, Marcus J, Phelps E, Wong WF, Marchesi J, Mullish BH, McDonald JA, Pechlivanis A, Barker GF, Blanco JM, Sagi S, Bohm M, Kelly CR, Kassam Z, Grinspan A, Fischer Met al., 2019,
  , Gastroenterology, Vol: 156, Pages: S-2-S-3, ISSN: 0016-5085
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• Journal article
  Churchward MA, Michaud ER, Blanco JM, Garcia-Perez I, Mullish BH, Marchesi J, Xu H, Kao DH, Todd Ket al., 2019,
  , Gastroenterology, Vol: 156, Pages: S-455-S-455, ISSN: 0016-5085
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• Journal article
  McDonald JA, Perez JL, Mullish BH, Marchesi Jet al., 2019,
  , Gastroenterology, Vol: 156, Pages: S-898-S-898, ISSN: 0016-5085
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• Journal article
  Abdul Rahim MBH, Chilloux J, Martinez-Gili L, Neves AL, Myridakis A, Gooderham N, Dumas M-Eet al., 2019,
  , Acta Diabetologica, Vol: 56, Pages: 493-500, ISSN: 0940-5429

  The human gut is a home for more than 100 trillion bacteria, far more than all other microbial populations resident on the body's surface. The human gut microbiome is considered as a microbial organ symbiotically operating within the host. It is a collection of different cell lineages that are capable of communicating with each other and the host and has an ability to undergo self-replication for its repair and maintenance. As the gut microbiota is involved in many host processes including growth and development, an imbalance in its ecological composition may lead to disease and dysfunction in the human. Gut microbial degradation of nutrients produces bioactive metabolites that bind target receptors, activating signalling cascades, and modulating host metabolism. This review covers current findings on the nutritional and pharmacological roles of selective gut microbial metabolites, short-chain fatty acids, methylamines and indoles, as well as discussing nutritional interventions to modulate the microbiome.

  • Abstract
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• Conference paper
  Ghani R, Gan C, Mullish B, Ferizoli V, Thursz M, Marchesi J, Davies F, Dasgupta R, Minhas Set al., 2019,
  , AUA 2019, Publisher: Elsevier, ISSN: 0022-5347
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• Journal article
  Ahmed B, Cox M, Cuthbertson L, James P, Cookson W, Davies J, Moffatt M, Bush Aet al., 2019,
  , Scientific Reports, Vol: 9, ISSN: 2045-2322

  The pathogenesis of airway infection in cystic fibrosis (CF) is poorly understood. We performed a longitudinal study coupling clinical information with frequent sampling of the microbiota to identify changes in the airway microbiota in infancy that could underpin deterioration and potentially be targeted therapeutically. Thirty infants with CF diagnosed on newborn screening (NBS) were followed for up to two years. Two hundred and forty one throat swabs were collected as a surrogate for lower airway microbiota (median 35 days between study visits) in the largest longitudinal study of the CF oropharyngeal microbiota. Quantitative PCR and Illumina sequencing of the 16S rRNA bacterial gene were performed. Data analyses were conducted in QIIME and Phyloseq in R. Streptococcus spp. and Haemophilus spp. were the most common genera (55% and 12.5% of reads respectively) and were inversely related. Only beta (between sample) diversity changed with age (Bray Curtis r2 = 0.15, P = 0.03). Staphylococcus and Pseudomonas were rarely detected. These results suggest that Streptococcus spp. and Haemophilus spp., may play an important role in early CF. Whether they are protective against infection with more typical CF micro-organisms, or pathogenic and thus meriting treatment needs to be determined.

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• Conference paper
  Ovadia C, Perdones-Montero A, Mullish B, McDonald J, Wahlstrom A, Dixon P, Walters J, Marschall H-U, Marchesi J, Williamson Cet al., 2019,

  Ursodeoxycholic acid treatment of cholestatic pregnancy can alter the gut microbiota to enhance bile acid modification and production of metabolically-active secondary bile acids - an explanation for 'responders' and 'non-responders'?

  , Publisher: WILEY, Pages: 17-17, ISSN: 1470-0328
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• Journal article
  Mcilroy JR, Segal JP, Mullish BH, Nabil Quraishi M, Gasbarrini A, Cammarota G, Ianiro Get al., 2019,
  , Human Microbiome Journal, Vol: 11, Pages: 100045-100045, ISSN: 2452-2317
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