
Researchers in the Section of Metabolic Medicine conduct clinical studies in people living with all forms of diabetes. Our overarching aim is to improve prevention, treatment, and long-term health outcomes for individuals with diabetes. This is achieved through patient-centred clinical research, analysis of electronic health records, and population-based studies.
Our work spans four key areas of research:
Early-Onset Type 2 Diabetes
leads a team investigating the heterogeneity of early-onset type 2 diabetes across diverse ancestries, with the goal of advancing precision medicine approaches. Her team utilises population datasets and early-onset diabetes cohorts, including the MY DIABETES study, to better understand disease mechanisms and outcomes.
Type 1 Diabetes and the ADDRESS-2 Study
Our researchers coordinate ADDRESS-2, one of the largest cohorts of adults with newly diagnosed type 1 diabetes. This study has provided novel insights into the pathophysiology of type 1 diabetes, with ongoing research examining the role of viral infections in disease development. ADDRESS-2 is led by and .
Leveraging Real-World Data for Diabetes
, , and their team lead studies that apply real-world data to improve population health, inform healthcare interventions, and enhance diabetes care delivery across England. Their work ensures the effective implementation and quality assurance of targeted interventions at a national scale.
Diabetes Technology
and lead research on emerging and existing technologies for diabetes management. Their studies focus on the application of continuous glucose monitoring, hybrid closed-loop systems, and digital health innovations to improve outcomes for people with type 1 and type 2.
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- - learning about the characteristics of people newly diagnosed with type 1 diabetes in the UK and supporting other research into type 1 diabetes.
- ABC4D study - Advanced Bolus Calculator for Diabetes.
- - Assessment of the Impact of Real-Time Continuous Glucose Monitoring on People Presenting With Severe Hypoglycaemia.
- - Assessment of the Accuracy of Continuous Glucose Sensors in People With Diabetes Undergoing Haemodialysis.
- ARISES – Adaptive, Real-time, Intelligent System to Enhance Self-care of chronic disease.
- - Clinical Evaluation of an Artificial Pancreas in people with Type 1 Diabetes.
- - Comparison of Continuous Glucose Monitoring vs. Flash Glucose Monitoring in Type 1 diabetes.
- - The impact of predictive hypoglycaemia alert function in physical activity for people with T1DM.
- PEPPER study - Personalised Decision Support system for diabetes management in Type 1 Diabetes.
- MY DIABETES study - Characterising Young-Onset Diabetes in two UK ethnic groups, specifically identifying potential genetic causes to their diabetes known as Maturity Onset Diabetes of the Young (MODY).
- The Wynn Database - Metabolic Risk Factors and Mortality
Head of Section of Metabolic Medicine
Research Groups
- Population health analytics and implementation group - Professor Jonathan Valabhji
Collaborations
Section leadership
Head of Metabolic Medicine - Dr Shivani Misra
Dr Shivani Misra is a Wellcome Trust Clinical Career Development Fellow & a Senior Clinical Lecturer within 911今日黑料 & Honorary Diabetes Consultant. Dr Misra has two main areas of research interest and clinical expertise: 1) She leads a portfolio of studies that investigate the genetics, epidemiology, classification and treatment of early-onset type 2 diabetes, defined as a diagnosis of type 2 diabetes in childhood or early-adulthood. 2) She investigates type 2 diabetes heterogeneity & precision medicine efforts in type 2 diabetes focussing on population diversity & health equity
Research group leads:
Dr Lala Leelarathna
Dr David Hope
Dr Ian Godsland
Professor Des Johnston
Professor Jonathan Valabhji
Professor Nick Oliver
Dr Parizad Avari
Dr Monika Reddy
Contact us
Ms Shazi Singh
shazi.singh@imperial.ac.uk