In this section
@article{Chen:2026:10.1039/d5qi01745a,
author = {Chen, H and Lim, Kee Chang W and Mcmullon, GT and Yu, Y and Woolley, BP and Geoghegan, G and Yalcin, C and Morse, SV and Lythgoe, MF and Choi, JJ and Long, NJ},
doi = {10.1039/d5qi01745a},
journal = {Inorganic Chemistry Frontiers},
pages = {63--73},
title = {Tetrazine-<i>trans</i>-cyclooctene ligated lanthanide conjugates for biomedical imaging},
url = {http://dx.doi.org/10.1039/d5qi01745a},
volume = {13},
year = {2026}
}
TY - JOUR
AB - Lanthanide chelates and copper-free ‘click’ chemistry have important uses for targeted molecular imaging and therapeutic strategies. Herein, we report the complexation of lanthanides to a tetrazine-functionalised DO3A macrocyclic chelator and the tetrazine-TCO ligation between the lanthanide(DO3A-tetrazine) complexes and a TCO-PEG4-functionalised rhodamine as a model agent. The luminescent and magnetic properties of the resultant dual-modal conjugates are described. The tetrazine moiety was found to sensitise terbium luminescence, resulting in a ‘turn-off’ effect upon its transformation to the dihydropyridazine linker, with the rhodamine moiety then dominating the fluorescence emissions. The T1 relaxivities of Gd(DO3A-tetrazine) and Gd(DO3A-PEG4-rhodamine) were found to be similar to [Gd(DOTA)]− (Dotarem®). As a proof-of-concept in vivo test, the click conjugates were delivered to mice brains using the combination of focused ultrasound and microbubbles, with neuron uptake of the probes observed.
AU - Chen,H
AU - Lim,Kee Chang W
AU - Mcmullon,GT
AU - Yu,Y
AU - Woolley,BP
AU - Geoghegan,G
AU - Yalcin,C
AU - Morse,SV
AU - Lythgoe,MF
AU - Choi,JJ
AU - Long,NJ
DO - 10.1039/d5qi01745a
EP - 73
PY - 2026///
SN - 2052-1545
SP - 63
TI - Tetrazine-<i>trans</i>-cyclooctene ligated lanthanide conjugates for biomedical imaging
T2 - Inorganic Chemistry Frontiers
UR - http://dx.doi.org/10.1039/d5qi01745a
UR - https://pubs.rsc.org/en/content/articlelanding/2026/qi/d5qi01745a
VL - 13
ER -
Professor Nick Long
Email: n.long@imperial.ac.uk
Telephone: +44 (0)20 7594 5781
501J
Molecular Sciences Research Hub
White City Campus
