Interventions for healthcare and country-wide settings

In this section

To ensure preparedness for a pandemic, experts at 911��պ�� are finding:

New ways to treat patients, including tools to help clinicians determine treatment in a dynamically changing and unknown environment.
Interventions for healthcare settings that help disrupted healthcare systems to function
Interventions and technologies that can be deployed nationally and internationally.
New vaccines

New and repurposed drugs

: Convergence science approaches to drug delivery and biomarker detection. Example (in Covid): Repurposing of drugs for COVID-19.
: Drug repurposing and interventions with TRV027 an antagonist of Angiotensin-II.
: Polymer- and lipid-based nanoparticles for targeted delivery of active pharmaceutical agents including nucleic acids and proteins. In Covid (example): Thermostable RNA formulations for vaccines and therapeutics.
: Drug design and translational immunology. Example (in Covid): Engineering of protein-based drugs that deal with cytokine storm inflammation after SARS-CoV-2 infection.
: Inhibitor drug discovery. Example (in Covid): Acrylamide inhibitors for the treatment of Covid-19.
: Identification of targets for host-directed antiviral therapies and antiviral testing through large scale screening.
: Using computational pipelines for in silico drug screening leveraging single-cell and spatial transcriptomics datasets.
: Repurposing of biologics that target fibroproliferation, with the aim of preventing fibrosis in at-risk patients. Example (in Covid): New therapies and repurposed therapies for severe COVID-19 by investigating key driving signatures of fibrosis and necrosis in the lungs.
: Vascular biology and vascular haemostasis. Example (in Covid): Anti-thrombotic drugs for severe COVID-19 infection.
: Respiratory and transplant medicine, e.g., immunomodulatory therapy.

Drug regimens and clinical decision-making

: Clinical translation, treatment decision-making, access to medicine, patient safety. Example (in Covid): COVID-19 treatment guidelines group.
: Artificial intelligence for clinical decision-making. Example (in Covid): AI prediction of best treatment for Covid-19 patients.
: Clinical and translational research. Example: Assessing treatments for critically ill COVID-19 patients in an adaptive platform trial – REMAP-CAP.
: Antimicrobial resistance. Example (in Covid): AI for clinical decision-making around antibiotic prescriptions for COVID-19 patients.
: Scientific advice on the use of antivirals in respiratory infections and pandemic preparedness.
: Treatment of influenza (anti-virals, immune modulation) and exploring their impact on viral resistance (via REMAP CAP platform trial).

Interventions for healthcare settings

Interaction of the human body with (medical) devices; Friction science for clinical applications, including PPE for healthcare workers. Example (in Covid): Lubricant performance to reduce COVID-19 PPE-related skin injury.
Low-cost ventilators for use in LMICs.
: Nanotechnology solutions for infection, including self-disinfecting surfaces (e.g. for masks/air-filter devices), drug delivery, and diagnostics. Example (in Covid): Toward nanotechnology-enabled approaches against the COVID-19 pandemic.
: Advanced manufacturing and design engineering. Example (in Covid): Custom-made PPE for frontline healthcare workers.
: Healthcare epidemiology and infection prevention and control. Example (in Covid): Healthcare SARS-CoV-2 transmission and interventions (e.g., precision prescribing, HEPA-based air decontamination systems, single patient rooms).
Engineering solutions to reducing the spread of aerosols in hospital wards. Example (in Covid): Development of Zephyr hood – an aerosol contaminant device.
: Cancer epidemiology and prevention. Example (in Covid): Understanding and interventions for the accumulating number of undiagnosed cases of cancer and cardiovascular disease due to the COVID-19 pandemic.
: Laser optics and software to study aerosol generation. Example (in Covid): New protocols for safe delivery of dental care during Covid-19.
: Low-cost ventilators for use in LMICs.

Interventions for public health and society

: Incentives for innovation and access to innovation. Example: Balancing sustainability of innovation with sustainability of healthcare.
: Low-power electronics and app design. Example (in Covid): Contact tracing app for Covid-19 built on privacy design principles.
: Computation and AI for health and disease; AI to identify bioactive compounds in foods with antiviral properties; precision nutrition strategies to support future pandemic preparedness. Example (in Covid): An AI-powered patient triage platform for future viral outbreaks; 'hyperfoods' to target SARS-CoV-2 host-pathogen interactions.

New vaccines

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