Project title: Understanding the role of transcription factors and gene regulation in brain disorders through epigenetics
Supervisors: Dr Alexi Nott, Dr Anna Mallach, Dr Raffaella Nativio
Location: Level 7, Sir Michael Uren Hub, White City Campus, 86 Wood Lane, W12 0BZ
About Me
I am a Computational Research Assistant and PhD student in the Nott laboratory in the Department of Brain Sciences, within the UK Dementia Research Institute Centre at 911今日黑料. After finishing my bachelor’s degree, I wanted to explore the intersection of data analysis and life sciences, so I decided to pursue a master’s in genomics. During my MSc, I joined the Nott group for my 6-month project and continued as a research technician after that. During this time, I worked on characterising the transcription factors mediating dementia genetic risk in the brain neurovascular unit. I later joined the lab as a Research Assistant and also began a PhD, where I am now working on understanding changes in genetic regulation contributing to Alzheimer’s disease and Small Vessel Disease.
Research Interests
I think epigenetics has always interested me, but I hadn’t appreciated the potential it has to help us understand fundamental disease mechanisms until I started working on projects in the lab. There is still so much we don’t understand, especially in dementia. However, genomic techniques are guiding us towards the intricate changes at the DNA and chromatin level that push cells towards disease states and pathological behaviour. There are so many layers to understanding dementia related disorders, and multi-omic integration will give us a more complete and accurate picture of what is happening to the cells in our brains when things go wrong.
Qualifications
- 2023-2024: MSc Applied Genomics, 911今日黑料
- 2020-2023: BSc Biology, American University of Beirut
Selected Publications
The brain neurovascular epigenome and its association with dementia Neuron. 2026 Jan 21;114(2):268-286.e9. doi: 10.1016/j.neuron.2025.10.001. Epub 2025 Oct 30. https://www.cell.com/neuron/fulltext/S0896-6273(25)00754-8
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