Citation

BibTex format

@article{Ness:2025:10.1038/s44318-024-00324-w,
author = {Ness, N and Diaz, Clavero S and Hoekstra, M and Brancaccio, M},
doi = {10.1038/s44318-024-00324-w},
journal = {The EMBO Journal},
pages = {356--381},
title = {Astrocytic GABA produced from polyamines synchronizes neuronal circadian timekeeping in the suprachiasmatic nucleus},
url = {http://dx.doi.org/10.1038/s44318-024-00324-w},
volume = {44},
year = {2025}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Astrocytes of the suprachiasmatic nucleus (SCN) can regulate sleep-wake cycles in mammals. However, the nature of the information provided by astrocytes to control circadian patterns of behavior is unclear. Neuronal circadian activity across the SCN is organized into spatiotemporal waves that govern seasonal adaptations and timely engagement of behavioral outputs. Here, we show that astrocytes across the mouse SCN exhibit instead a highly uniform, pulse-like nighttime activity. We find that rhythmic astrocytic GABA production via polyamine degradation provides an inhibitory nighttime tone required for SCN circuit synchrony, thereby acting as an internal astrocyte zeitgeber (or “astrozeit”). We further identify synaptic GABA and astrocytic GABA as two key players underpinning coherent spatiotemporal circadian patterns of SCN neuronal activity. In describing a new mechanism by which astrocytes contribute to circadian timekeeping, our work provides a general blueprint for understanding how astrocytes encode temporal information underlying complex behaviors in mammals.
AU  - Ness,N
AU  - Diaz,Clavero S
AU  - Hoekstra,M
AU  - Brancaccio,M
DO  - 10.1038/s44318-024-00324-w
EP  - 381
PY  - 2025///
SN  - 0261-4189
SP  - 356
TI  - Astrocytic GABA produced from polyamines synchronizes neuronal circadian timekeeping in the suprachiasmatic nucleus
T2  - The EMBO Journal
UR  - http://dx.doi.org/10.1038/s44318-024-00324-w
UR  - https://www.embopress.org/doi/full/10.1038/s44318-024-00324-w
VL  - 44
ER  -
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