Notable Recent Publications

These are some recent publications which give a flavour of the research from the Barclay lab. For a complete list of publications, please see below.

Jason S. Long, Efstathios S. Giotis, Olivier Moncorgé, Rebecca Frise, Bhakti Mistry, Joe James, Mireille Morisson, Munir Iqbal, Alain Vignal, Michael A. Skinner & Wendy S. Barclay

This paper identified a key factor that explained why the polymerases from avian influenza viruses are restricted in humans.  For more, please see the associated .

See our latest ANP32 papers here: ,, .

Daniel H. Goldhill, Aartjan J. W. te Velthuis, Robert A. Fletcher, Pinky Langat, Maria Zambon, Angie Lackenby & Wendy S. Barclay

This paper showed how influenza could evolve resistance to favipiravir, an antiviral that may be used to treat influenza. The residue that mutated to give resistance was highly conserved suggesting that the mechanism of resistance may be applicable to other RNA viruses.

Hui Li*, Konrad C. Bradley*, Jason S. Long, Rebecca Frise, Jonathan W. Ashcroft, Lorian C. Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao & Wendy S. Barclay

Why do avian influenza viruses like H5N1 cause such severe disease in humans? This paper demonstrated that H5N1 viruses replicate better than human viruses in myeloid cells from mice leading to a cytokine storm and more severe disease.

Citation

BibTex format

@article{Braga:2021:10.1038/s41586-021-03491-6,
author = {Braga, L and Ali, H and Secco, I and Chiavacci, E and Neves, G and Goldhill, D and Penn, R and Jimenez-Guardeno, JM and Ortega-Prieto, AM and Bussani, R and Cannata, A and Rizzari, G and Collesi, C and Schneider, E and Arosio, D and Shah, AM and Barclay, WS and Malim, MH and Burrone, J and Giacca, M},
doi = {10.1038/s41586-021-03491-6},
journal = {NATURE},
pages = {88--+},
title = {Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia},
url = {http://dx.doi.org/10.1038/s41586-021-03491-6},
volume = {594},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AU  - Braga,L
AU  - Ali,H
AU  - Secco,I
AU  - Chiavacci,E
AU  - Neves,G
AU  - Goldhill,D
AU  - Penn,R
AU  - Jimenez-Guardeno,JM
AU  - Ortega-Prieto,AM
AU  - Bussani,R
AU  - Cannata,A
AU  - Rizzari,G
AU  - Collesi,C
AU  - Schneider,E
AU  - Arosio,D
AU  - Shah,AM
AU  - Barclay,WS
AU  - Malim,MH
AU  - Burrone,J
AU  - Giacca,M
DO  - 10.1038/s41586-021-03491-6
EP  - 88
PY  - 2021///
SN  - 0028-0836
SP  - 88
TI  - Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia
T2  - NATURE
UR  - http://dx.doi.org/10.1038/s41586-021-03491-6
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000657457400022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL  - 594
ER  -
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Contact us

For any enquiries related to this group, please contact:

Professor Wendy Barclay
Chair in Influenza Virology 
+44 (020) 7594 5035
w.barclay@imperial.ac.uk